Database : HANSEN Search on : MYCOBACTERIUM LEPRAE/CRESC [Subject descriptor] References found : 92 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 19686 Author: anon. Title: Editorial: Mycobacterium leprae Iron Nutrition: Bacterioferritin, Mycobactin, Exochelin and Intracellular Growth. Source: Int. J. Lepr;63(1):86-91, 1995. . Descriptors: Mycobacterium leprae/cresc Mycobacterium leprae/fisiol Bacteriocinas/anal Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1995/pdf/v63n1/v63n1edt.pdf / en Location: BR191.1

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Id: 18509 Author: Bakker, M. I; Hatta, M; Kwenang, A; Faber, W. R; Van Beers, S. M; Klatser, P. R; Oskam, L. Title: Population survey to determine risk factors for Mycobacterium leprae transmission and infection. Source: In: Bakker, Mirjam.Epidemiology and prevention of leprosy: a cohort study in Indonesia^ien. s.l, The Netherlands Leprosy Relief, 2005. p.72-86^bmapas, ^btab. Abstract: Background: Not every leprosy patient is equally effective in transmitting Mycobacterium leprae. We studied the spatial distribution of infection (using seropositivity as a marker) in the population to identifity which disease characteristics of leprosy patients are important in transmission. Methods: Clinical data and blood samples for anti-M.leprae ELISA were collected during a cross-sectional survey on five Indonesian islands highly endemic for leprosy. A geographic information system (GIS) was used to define contacts of patients. We investigated spatial clustering of patients and seropositive people and used logist regression to determine risk factors for seropositivity. Results: Of the 3986 people examined for leprosy, 3271 gave blood. Seroprevalence varied between islands (1.7-8.7%) and correlated significantly with leprosy prevalence. Five clusters of patients and two clusters of seropositives were detected. In multivariate analysis, seropositivity significantly differed to be the best discriminator of contact groups with higher seroprevalence: contacts of seropositive patients had an adjusted odds ratio (aOR) of 1.75 (95% CI: 0.92-3,31). This increased seroprevalence was strongest for contact groups living _< 75 metres of two seropositive patients (aOR:3.07;95%CI:1.74-5.42). Conclusions: In this highly endemic area for leprosy, not only household contacts of seropositive patients, but also persons living in the vicinity of seropositive patient were more likely to harbour antibodies against M.leprae. Through measuring the serological status of patients and using a broader definition of contacts, higher risk groups can be more specifically identified (AU)^ien. Descriptors: HANSENIASE/epidemiol MYCOBACTERIUM LEPRAE/cresc ELISA/normas ELISA/util MODELOS LOGISTICOS Limits: ESTUDO COMPARATIVO Humanos Location: BR191.1; WC335.300, B179e

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Id: 18507 Author: Bakker, Mirjam. Title: Introduction. Source: In: Bakker, Mirjam.Epidemiology and prevention of leprosy: a cohort study in Indonesia^ien. s.l, The Netherlands Leprosy Relief, 2005. p.10-54^bmapas, ^btab, ^bgraf. Descriptors: HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/prev MYCOBACTERIUM LEPRAE/clas MYCOBACTERIUM LEPRAE/cresc HANSENIASE/hist HANSENIASE/reabil HANSENIASE/terap Limits: ESTUDO COMPARATIVO Humanos Location: BR191.1; WC335.300, B179e

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Id: 18506 Author: Bakker, Mirjam Title: Epidemiology and prevention of leprosy: a cohort study in Indonesia^ien ..- Source: s.l; The Netherlands Leprosy Relief; 2005. 165 p. ^bilus, ^bmapas, ^btab, ^bgraf. Abstract: Leprosy is an infectious disease caused by Mycobacterium leprae, a bacterium which primarily affects the nerves and skin. Worldwide 513,798 new patients were detected in 2003. Trend analysis showed that the new case detection rate did not decline between 1985 and 2000. Leprosy diagnosis is aminly based on the presence of skin lesions, loss of sensitivity and thickened nerves. The clinical pattern varies widely between patients due to a different level of celular immunity that an infected person mounts to the infection. For treatment purposes patients are divided into paucibacillary (PB) and multibacillary (MB) patients. Effective treatment against leprosy is available (chapter 1). In the last five decades cohort studies have investigated risk factors for developing leprosy. Most of these studies were conducted among contacts of leprosy patients and a few were population-based. Risk factors for developing leprosy were grouped into three levels: (1) individual level; (2) household and community levels; (3) meso/macro levels (chapter 1). As leprosy case detections rates did not decline in the last 15 years despite effective multi-drug treatment, new approaches and strategies to definitely eliminate leprosy as a public health problem are required. Four research questions were addressed in this thesis: "Which patients transmit leprosy?", "What are risk factors for developing leprosy?", "Can rifampicin, used as chemoprophylaxis, prevent leprosy?" and "How can chemoprophylaxis be most efficiently implemented?". All studies presented in this thesis were preformed in the same study area, five geographically isolated islands in the Flores Sea, Indonesia, and are part of still continuing population-based cohort study. Chaper 2 mainly serves as background information on the leprosy epidemic in the study area. It describes how an enormous load of backlog patients existed on these islands, with only irregular leprosy control before 2000. The overvall new case detection ra...(AU)^ien. Descriptors: HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/prev INDONESIA/epidemiol MYCOBACTERIUM LEPRAE/quim MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/fisiol Limits: ESTUDO COMPARATIVO Location: BR191.1; WC335.300, B179e

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Id: 18499 Author: Hansen, G. A Title: Études sur la bacterie de la lèpre^ifr Studies on the leprosy bacterium- Source: s.l; s.n; 1882. 11 p. . Abstract: La question de la contagiosit‚ de la lèpre n'a pas frait de progres dans ces dernières ann‚es, malgr‚ les travaux de Neisser (1) et Kubner (2). (AU)^ifr. Descriptors: HANSENIASE/microbiol HANSENIASE/fisiopatol HANSENIASE/parasitol HANSENIASE/transm HANSENIASE/virol MYCOBACTERIUM LEPRAE/citol MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/fisiol MYCOBACTERIUM LEPRAE/patogen Location: BR191.1; 01054/d.a

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Id: 18470 Author: Lowe, John. Title: Repetição dos exames dos casos de lepra / Repetition of examinations of cases of leprosy with high Source: Rev. Lepr. São Paulo;1(1):28-30, Set. 1933. ^btab. Descriptors: Hanseníase/diag Hanseníase/microbiol Hanseníase/patol Hanseníase/fisiopatol Hanseníase/virol Mycobacterium leprae/cresc Mycobacterium leprae/isol Mycobacterium leprae/metab Mycobacterium leprae/patogen Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/leprolsp/1933/PDF/v1n1/v1n1a06.pdf / pt Location: BR191.1

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Id: 18437 Author: Weber, Karl Title: Werden die leprabacillen von einem leprakranken ausgeschieden, und auf welche weise verlassen sie den körper? Will the leprabacillen by a retired lepers, and what they leave the body?- Source: Leipzig; s.n; 1897. 24 p. . Thesis: Present for Friedrichs-Universität Halle-Wittenberg presented for the degree Doctor. Descriptors: HANSENIASE/diag HANSENIASE/fisiopatol MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/fisiol Limits: ESTUDO COMPARATIVO Location: BR191.1; WC335.400, W38w

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Id: 18390 Author: Ebenezer, G. J; Norman, G; Joseph, G. A; Daniel, S; Job, C. K Title: Drug resistant-Mycobacterium leprae- results of mouse footpad studies from a laboratory in South India ..- Source: s.l; s.n; 2002. 12 p. tab. Abstract: Out of 265 biopsies of leprosy patients received at the Experimental Laboratory of Schieffelin Leprosy Research and Training Centre from 1987 to 1997 for evaluating resistant strains of M. leprae using the mouse footpad technique, 49 showed resistant strains of M. leprae to varying concentration of dapsone, rifampicin and clofazimine. 23 (47%) of these were from a control area. With 369 skin-smear positive multibacillary (MB) patients as the risk group (denominator), 23 (6.23%) were resistant to one or more drugs. 18 (4.88%) had dapsone resistance, 5 (1.36%) were resistant to rifampicin and 9 (2.44%) had resistance to low concentrations of clofazimine (0.0001%). Out of the 23 biopsies with drug resistance from the control area, primary dapsone resistance was seen in 7 (30%) biopsies and secondary dapsone resistance in 11 (48%). Primary rifampicin resitance was seen in 4 (17.4%) patients, secondary rifampicin resistance in 1 (4.35%) and primary clofazimine resistance in 7 (30%). 3 (13%) of the strains showed secondary clofazimine resistance. One biopsy had resistent strains to all the three drugs. In a control area where properly supervised effective multidrug therapy (MDT) was regularly administered over the years, the emergence of drug resistance is negligible. It may not be the case if the content, duration and regularity of the drug regimen were not satisfactory. Aware of the possible shortcomings in mass administration of MDT, it is emplasized that mouse footpad studies on drug resistance should be made available at least in endemic areas where the incidence of the disease has not changed despite good MDT coverage in order to monitor the emergence of drug resistance. Research into molecular biological identification of drug resistant-M.leprae should be intensified. These steps would help to institute timely measures to check the spread of any drug-resistant organisms in the community (AU). Descriptors: MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/isol MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM LEPRAE/patogen MYCOBACTERIUM LEPRAE/ultraest RESISTÊNCIA A DROGAS DAPSONA/uso terap CLOFAZIMINA/uso terap RIFAMPINA/uso terap TESTES DE SENSIBILIDADE MICROBIANA/métodos TESTES DE SENSIBILIDADE MICROBIANA/vet - HANSENIASE/clas  HANSENIASE/compl  HANSENIASE/quimioter  HANSENIASE/imunol  HANSENIASE/microbiol  HANSENIASE/patol  OFLOXACINO/uso terap  MINOCICLINA/uso terap Limits: HUMANO Location: BR191.1; 09299/s

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Id: 18389 Author: Rambukkana, Anura Title: Mycobacterium leprae-induced demyelination: a model for early nerve degeneration ..- Source: s.l; s.n; 2004. 7 p. ilus. Abstract: The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstratation of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration (AU). Descriptors: DOENCAS DESMIELINIZANTES/etiol DOENCAS DESMIELINIZANTES/imunol DOENCAS DESMIELINIZANTES/microbiol DOENCAS DESMIELINIZANTES/patol MYCOBACTERIUM LEPRAE/quim MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/patogen - DEGENERACAO NEURAL/etiol  DEGENERACAO NEURAL/patol  HANSENIASE/compl  HANSENIASE/imunol  HANSENIASE/microbiol  HANSENIASE/patol Limits: HUMANO Location: BR191.1; 09300/s

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Id: 18331 Author: Nakamura, K; Yogi, Y Title: The nude mouse as an experimental lepromatous leprosy model: the enhancing effect of thymus cells in infected ?- Source: Tokyo; s.n; 1980. 6p p. ilus. Abstract: In sumary, it may well be conculuded that the nude mouse with thymus cell grafting as a severe lepromatous leprosy model was developed in C57BL/6-nu/nu as well as CF#1-nu/nu, comparing with untreated nude mice. In addtion, comparison of sex in treated group, susceptibility to M. leprae in the some males were higher than in foot swelling of the females, also, difference of individuality occured in both sex at a latter stage after infection, therefore, further investigation is under way to look for preferable nude mouse and hairless-athymic mouse which they are established by ourselves. Descriptors: RATOS NUDE/imunol RATOS NUDE/les RATOS NUDE/microbiol MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/isol MYCOBACTERIUM LEPRAE/patogen - HANSENIASE VIRCHOWIANA/transm Limits: ANIMAL Location: BR191.1; 00365/s

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Id: 18265 Author: Antia, Noshir H Title: Persistence of Mycobacterium leprae in the peripheral nerve ..- Source: s.l; s.n; 1983. 422 p. tab. Descriptors: NERVOS PERIFERICOS/microbiol NERVOS PERIFERICOS/fisiol NERVOS PERIFERICOS/virol MYCOBACTERIUM LEPRAE/citol MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM LEPRAE/fisiol MYCOBACTERIUM LEPRAE/patogen MYCOBACTERIUM LEPRAE/virol HANSENIASE/imunol Limits: RELATO DE CASO Location: Br191.1; 01942/S

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Id: 18235 Author: Roy, A. N Title: Some interesting observations on the cultivation Mycobacterium leprae ..- Source: s.l; s.n; 1966. 2 p. . Abstract: A preliminary report on cultivation of Mycobacterium leprae in artificial media is reported.The work suggests that the modified medium used in this work may help in cultivating Mycobacteria leprae (AU). Descriptors: MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/isol MEIOS DE CULTURA/quim - MICROSCOPIA/util Limits: IN VITRO Location: BR191.1; 09280/s

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Id: 18102 Author: Fernández, J. M. M Title: The early reaction induced by lepromin ?- Source: Rosario; s.n; 1940. 13p p. . Abstract: The intradermal reaction to lepromin has been studied in a total of 563 persons, cases of leprosy and contacts. Observation of its clinical and histopathologic development has shown the following facts:a- In allergic cases intradermal injection of lepromin induces an "early" reaction which is well defined, both clinically and histologically, beginning a few hours after injection and reaching its maximum between 48 and 72 hours, thereafter decreasing until it disappears completely during the first week. b- This early reaction, which is manifested clinically by an erythematous halo, usually infiltrated, is not of nonspecific character since it has the histologic structure common to allergic reactions and is only seen in those cases which offer resistance to the infection (i.e., neural forms of the disease, particularly the tuberculoid form) and does not occur in cases which are considered anergic, as in the lepromatous type...AU. Descriptors: ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/ef drogas ANTIGENO DE MITSUDA/uso diag - MODELOS ANIMAIS  MYCOBACTERIUM LEPRAE/cresc  MYCOBACTERIUM LEPRAE/patogen Limits: ANIMAL Location: BR191.1; 00716/s

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Id: 18094 Author: Garfield, Eugene Title: Leprosy: down not out ..- Source: s.l; s.n; 1980. 8 p. . Descriptors: HANSENIASE/compl HANSENIASE/hist MYCOBACTERIUM LEPRAE/cresc - ANIMAIS DE LABORATORIO/les  DAPSONA/uso terap Limits: HUMANO Location: BR191.1; 00261/s

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Id: 18086 Author: Gunders, A. E Title: Progressive experimental infection with mycobacterium leprae in a chimpanzee ?- Source: s.l; s.n; 1958. 3p p. ilus. Descriptors: MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/isol MYCOBACTERIUM LEPRAE/patogen - MODELOS ANIMAIS Location: BR191.1; 00567/s

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Id: 17986 Author: Krahenbuhl, James L; Adams, Linda B. Title: Effects of microenvironment on local regulation of granulomas caused by Mycobacterium leprae. Source: Hansen. int;(n.esp):129-132, Jun. 1998. tab. Conference: Present in: Congresso da Associação Brasileira de Hansenologia, IX, Foz do Iguaçu, 04-08 junho 1997. Descriptors: MYCOBACTERIUM LEPRAE/citol MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/genet MYCOBACTERIUM LEPRAE/fisiol HANSENIASE/genet HANSENIASE/imunol HANSENIASE/fisiopatol Limits: RELATO DE CASO ESTUDO COMPARATIVO HUMANO Location: BR191.1

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Id: 17984 Author: Brennan, Patrick J. Title: Mycobacterium leprae: the significance of our knowledge of its composition and antigenicity. Source: Hansen. int;(n.esp):103-110, Jun. 1998. . Conference: Present in: Congresso da Associação Brasileira de Hansenologia, IX, Foz do Iguaçu, 04-08 junho 1997. Descriptors: MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/genet MYCOBACTERIUM LEPRAE/fisiol LINFOCITOS T CD4-POSITIVOS/citol LINFOCITOS T CD4-POSITIVOS/fisiol Limits: ESTUDO COMPARATIVO HUMANO Location: BR191.1

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Id: 17906 Author: Goulart, Isabela Bernardes; Dias, Cristiane de Moraes; Oliveira, Ana Carolina Souza; Silva, Amanda Ambrósio da; Alves, Rodrigo Rodrigues; Quaresemin, Camila Renault; Silva, Daniela Pereira da; Lopes, Márcia Regina Ferreira; Faria, Gustavo Andrade. Title: Grau de incapacidade: indicador de prevalência oculta e qualidade do programa de controle da hanseníase em um Centro de Saúde-Escola no município de Uberlândia - MG / Degree of incapacity: an indicator for hidden prevalence and program quality of leprosy control in a University Health Center in the Uberlândia District Source: Hansen. int;27(1):5-13, jan.-jun. 2002. tab, graf. Abstract: O longo período de incubaçäo da hanseníase, seus sintomas e sinais insidiosos, assim como as deficiências operacionais no Programa de Controle, produzem dificuldades em seu diagnóstico. Essa situaçäo cria condições para considerar que existe uma prevalência oculta que leva incapacidade ao doente e influi na cadeia de transmissäo. Este trabalho objetivou aplicar indicadores para análises epidemiológica e operacional do Programa de Controle da Hanseníase no Distrito Sanitário Oeste, Uberlândia-MG, avaliando as incapacidades físicas dos pacientes como medida da qualidade do programa e estimativa de prevalência oculta. Foram analisados 138 prontuários de hansenianos diagnosticados no Centro de Saúde Escola da Universidade Federal de Uberlândia (CSE-UFU), de janeiro de 1995 a julho de 2000. No diagnóstico, 24 por cento dos pacientes apresentaram algum grau de incapacidade, inclusive grau I, evidenciando diagnóstico tardio. Na alta, 68 por cento dos pacientes que iniciaram o tratamento com grau zero permaneceram nesse grau e, entre aqueles que iniciaram com grau I, 61,5 por cento mantiveram a condiçäo, 23,1 por cento regrediram para zero e 15,4 por cento näo tiveram registro. Os indicadores operacionais refletiram um atendimento de boa qualidade no CSE-UFU. A prevelência oculta estimada foi de 27 casos para o ano 2000, elevando a taxa de prevelência conhecida de 10,22/10.000 habitantes para a taxa de prevalência real de 13,67/10.000, evidenciando uma endemia muito alta de hanseníase no Distrito Oeste. Discute-se a necessidade de adotar a avaliaçäo do grau de incapacidades como indicador de morbidade e controle da doença nos vários níveis de atençäo a fim de planejar ações para detectar os focos de endemia oculta nas comunidades. (AU). Descriptors: HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/reabil SAUDE PÚBLICA/instrum SAUDE PÚBLICA/métodos MYCOBACTERIUM LEPRAE/cresc Limits: ESTUDO COMPARATIVO HUMANO Electronic Medium: http://hansen.bvs.ilsl.br/textoc/hansenint/v21aov29/2002/PDF/v27n1/v27n1a01.pdf / pt

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Id: 17896 Author: Deps, Patrícia Duarte. Title: Como o mycobacterium leprae é transmitido / How is the mycobacterium leprae transmitted? Source: Hansen. int;26(1):31-36, jan.-jun. 2001. . Abstract: A hanseníase ocorre em todo o mundo; contudo, a prevalência da doença é altamente variável e maior em países tropicais. Acredita-se que o modo mais comum de transmissäo, inter-humana, seja por secreçöes naso-respiratórias infectadas. O papel dos reservatórios naturais e a transmissäo zoonótica de outras epécies para o homem ainda permanece näo completamente entendido. Este artigo revisa os conhecimentos atuais concernentes aos potenciais reservatórios do Mycobacterium leprae tais quais solo, vegetaçöes, água e artópodes; anfíbios e mamíferos e o seu papel na doença humana. (AU). Descriptors: HANSENIASE/epidemiol HANSENIASE/microbiol MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/patogen MYCOBACTERIUM LEPRAE/virol Limits: ESTUDO COMPARATIVO HUMANO Electronic Medium: http://hansen.bvs.ilsl.br/textoc/hansenint/v21aov29/2001/PDF/v26n1/v26n1a04.pdf / pt Location: BR191.1

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Id: 17834 Author: Opromolla, D. V. A.. Title: Cultivation of M. leprae and those who study micobacteria. Source: Hansen. int;19(2):3-4, Dez. 1994. . Descriptors: MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/fisiol MYCOBACTERIUM LEPRAE/patogen Limits: ESTUDO COMPARATIVO Electronic Medium: http://hansen.bvs.ilsl.br/textoc/hansenint/v01aov20/1994/PDF/v19n2/v19n2edteng.pdf / en Location: BR191.1

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